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Our related article on GLP-1 Signaling, the Microbiome, and Hormones explains why GLP-1 biology is part of a larger metabolic network rather than a stand-alone weight-loss switch

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The Thigh Is Not Pharmacologically Inferior This is the part most people are actually asking about, and it has a clear answer in the clinical pharmacology section of the label: similar exposure was achieved with subcutaneous administration of semaglutide in the abdomen, thigh, or upper arm