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Clinical evidence has long suggested that the use of GLP-1 medications is linked to lower substance use. It's also been speculated among patients taking the medications. Social drinkers, for example, contend that

Weekly GLP-1 Medications Explained How GLP-1 Medications Work GLP-1 receptor agonists mimic a hormone your body naturally produces called glucagon-like peptide-1

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Genetic variations in the GLP1R gene (rs6923761), GIPR gene (rs1800437), and other peptide-pathway markers influence medication efficacy and side effect tolerance