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Why Hydration Matters on Weight Loss Medications

This observation supports the view that removing a “Leucine plug” by mechanical force [1,2, 5] is a key step in ligand-induced activation of Drosophila and vertebrate Notch, and further suggests that the Epsin-mediated pulling force is specifically required to accomplish this step

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This dual mechanism may contribute to greater reductions in HbA1c and body weight in clinical trials