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The first reference group included pregnancies of patients diagnosed with pre-existing diabetes mellitus (International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10 codes E10–E13), who were exposed to non-GLP1-RA antidiabetic drugs during the first trimester of pregnancy (in most cases metformin)

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It may not be the ideal first choice for someone who is highly medication-sensitive or primarily wants a very gentle introduction to GLP-1 therapy