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Oral antihistamine (cetirizine 10 mg or loratadine 10 mg) taken 1 hour before injection can reduce itching Topical hydrocortisone 1% cream applied to injection site twice daily for 2 to 3 days (not before injection, only after) Avoid topical Benadryl (diphenhydramine) cream, which can cause contact dermatitis Step 4: Track the pattern