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doi: 10.1136/gut.24.9.798
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Therefore, additional substitutions of Lys10 (for C16 acylation), Glu16 (for hydrolytic stability), Arg17 (Gcg-specific), Gln20 (GIP/Gcg-specific), Leu27 (GIP-specific), Asp28 (for solubility), and the addition of the Exendin-4 CEX tail, together established balanced affinity between all three receptors and served auxiliary functions to enhance chemical stability, solubility, and secondary structure (Table 2)
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