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PubMed Dahl, D., Onishi, Y., Norwood, P., Huh, R., Bray, R., Patel, H., & Rodríguez, Á
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Radiolabeled receptor binding assays show oxyntomodulin binds to the GLP-1R with an approximate 10-fold reduction in potency relative to native GLP-1, with a comparative 100-fold reduction in cAMP potency, indicating the extent of oxyntomodulin’s 8 amino acid C-terminal extension in conferring additional promiscuity at the GLP-1R [41]
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