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In a model of polymicrobial sepsis–induced lung inflammation, a single 10 μg/kg dose of semaglutide treatment suppressed lung Tnf , Il6 , and Il1b expression and attenuated lung neutrophil elastase staining 24 hours after infection, an effect absent in Glp1r Wnt1–/– mice with inactivation of neuronal GLP-1Rs (22)
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