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The targeting of signaling partners to GLP-1rs is likely mediated by in some areas by A-kinase anchoring protein (AKAP) scaffolding proteins, which have been shown to target PKA to GLP-1r(Lester et al., 1997)

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The research team opted for a method that directly compares periods when the same person took the drug with periods when they did not, minimizing errors due to individual differences