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• Biguanides (e.g., Metformin): ↓ Hepatic glucose production and ↑ insulin sensitivity

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In this context, it is worth noting that the line of evidence on GLP-1 RAs’ cardiovascular potency exceedingly grows, including the very recent publication of the SELECT trial in patients with pre-existing cardiovascular disease and overweight or obesity, 45 with GLP-1 RAs steadily claiming their place in cardiovascular disease prevention also beyond T2DM