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In mice, both acute and chronic central administration of exendin-4 increases HR and BP with concomitant decrease in excitatory glutamatergic and inhibitory glycinergic neurotransmission to preganglionic parasympathetic cardiac vagal neurons
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Medication:Tirzepatide (GLP-1 + GIP)
FDA Drug Safety Communication: FDA investigating reports of possible increased risk of pancreatitis and pre-cancerous findings of the pancreas from incretin mimetic drugs for type 2 diabetes
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