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Compared to the inactive GCGR, the extracellular tip of TM7 in peptide 20-bound GCGR moved outward by 5.1 Å (measured by Cα atom of L377 7.34b ) and the α-helical structure of the extracellular half of TM6 was partially unwounded
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Such a move has the potential to save tens of millions a year for the Commonwealth and its non-Medicare enrollees
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