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f dual mechanism of action: glucagon-like peptide 1 agonist and glucose-dependent insulinotropic polypeptide analogue FDA-APPROVED USES OF GLP-1 RECEPTOR AGONISTS GLP-1RA are FDA-approved for the treatment of diabetes mellitus, with a meta-analysis finding an average decrease in HbA1c ranging from 0.61% for lixisenatide to 2.1% for tirzepatide.[26] In addition, GLP-1RAs have been approved for three additional non-diabetes indications: weight management, cardiovascular risk reduction, and obstructive sleep apnea
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