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[DOI] [PubMed] [Google Scholar] [163].Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC, Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model, Diabetes, 61 (2012) 1250–1262

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Another promising direction involves mucoadhesive nanocarriers that anchor to intestinal epithelium and release GLP-1 analogs in a site-specific manner, minimizing systemic degradation [35]