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Oral GLP-1 therapies emerged as game-changers: Rybelsus (oral semaglutide) was approved for diabetes in 2019, and in December 2025 the FDA approved Wegovy’s first oral pill (25 mg semaglutide) for obesity ( [35] )

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Post hoc t -tests were performed to provide a measure toward proof of concept for various parameters at the end of dosing where the data distribution was assumed to be normal but this was not formally tested (Figs