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acting upon different organs such as the pancreatic islets, the hypothalamus or the stomach, for the release of insulin, to regulate food intake or gastric emptying respectively ( Surprisingly, this heterogeneous and highly plastic population of cells is known to differentiate from a single staminal progenitor that gives also rise to enterocytes, goblet and paneth cells ( It has been known for more than a century that the gut is capable to stimulate the endocrine portion of the pancreas and even improve the hyperglycaemic state of diabetic patients ( In the last three decades, the incretin-effect has been attributed primarily to two peptide hormones, the gastric-insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), excreted primarily by duodenal (K) and ileo-colonic (L) enteroendocrine cells respectively ( Obesity and Type 2 diabetes are chronic diseases for which the most effective treatment is bariatric surgery