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[2] [3] Based on the known class effects of GLP-1 and GIP receptor agonists, the following additional cautions are relevant, even where retatrutide-specific data are still emerging: Acute pancreatitis : Participants should be advised to seek urgent medical attention if they develop severe, persistent abdominal pain — particularly pain radiating to the back — accompanied by vomiting, as this may indicate pancreatitis

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Dozens of Trulicity patients are experiencing life-altering complications, including pancreatitis, gastroparesis, and sudden, irreversible blindness