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[Diagram suggestion: four-quadrant matrix with X-axis "weeks on therapy" and Y-axis "dose (mg)", showing the four phases as overlapping colored zones with representative dose trajectories plotted as curves] The model predicts that patients starting at 0.625 mg reach therapeutic threshold (2.5 mg) in 6 to 8 weeks versus 0 weeks for standard-start patients

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Subjects undergoing sino-nasal surgery were 0.0% (0/33) in the DUPIXENT group and 6.9% (2/29) in the placebo group