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Metabolic Syndrome (2026) Emphasis on visceral adiposity over BMI Expanded role of GLP-1 RA & dual incretins Early intervention even in prediabetes Focus on cardiovascular risk reduction Diagnosis = ≥3/5 criteria Most

Combining both requires careful baseline renal and metabolic screening, regular electrolyte monitoring, and provider oversight to detect cumulative toxicity

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Consistent access to therapy is also essential, as interruptions can worsen GI symptoms and reduce adherence