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Clinical trial dosing schedule Standard titration (from Phase 2 trials): Week-by-week escalation: Titration rationale: Reduces side effects (especially nausea) Allows body adaptation to GI effects Gradual weight loss healthier Similar to semaglutide / tirzepatide titration Cannot skip - jumps cause intolerable sides Target doses: 4mg: Minimum effective (17% loss) 8mg: Standard therapeutic (23% loss) 12mg: Maximum approved in trials (24% loss) Higher than 12mg: Not studied, unknown safety Administration: Route: Subcutaneous injection Frequency: Once weekly Location: Abdomen, thigh, or upper arm Timing: Same day each week (consistency) Use our peptide calculator and semaglutide calculator for similar titration planning at SeekPeptides