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Avery Brown of NYU Langone Health noted: “as many as 70% of patients may discontinue treatment within one year.” Patients who stayed on continuous GLP-1 therapy for a full year lost meaningfully more weight than those who didn’t — still less than surgery patients, but the researchers were explicit that adherence changes the picture substantially
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Similarly, in the combined case-control and cohort study by Wium-Andersen and colleagues, 33 low doses of metformin, DPP-4 inhibitors, GLP-1 analogs, and SGLT2 inhibitors were associated with a lower risk of depression in patients with diabetes compared to non users, with the lowest risk for sodium-glucose transport protein 2 inhibitor users
