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In the STEP trials (Semaglutide Treatment Effect in People with obesity), participants on 2.4mg achieved average weight loss of approximately 15% of body weight over 68 weeks, while lower-dose groups saw proportionally less dramatic reductions
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But exendin-4 had a property human GLP-1 lacked: resistance to degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)
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