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Who Should NOT Take GLP-1 for Weight Loss? | Gutwell
In December 2025, the TRIUMPH-4 trial reported that retatrutide 12 mg achieved a remarkable 28.7% mean weight loss at 68 weeks in patients with obesity and knee osteoarthritis, with substantial pain relief as well ( [73] )
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Medication:Tirzepatide (GLP-1 + GIP)
Their identification of the amino acid sequence of the biologically active GLP-1 hormone laid the groundwork for drugs in the management of type 2 diabetes
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