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therefore, investigation of potential individual-specific FFAR/incretin receptor functional interactions in the different locations where these receptors are co-expressed is paramount to determine if co-stimulation of both GPCR families might results in enhanced, reduced or biased GLP-1RA responses, an effect which might be regulated by the action of the microbiome
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The tradeoffs are medical oversight, cost, the injection route for many of these medicines, and a distinctive side-effect profile led by gastrointestinal symptoms
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