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It is FDA-approved for two indications: improving glycemic control in adults (and children aged 10 and older) with type 2 diabetes mellitus as an adjunct to diet and exercise, and reducing the risk of major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors

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7,8 If, however, the zymogens are activated prematurely before they exit the pancreatic interstitium, autodigestion of the peripancreatic tissue and pancreatic parenchyma can occur