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According to the 2021 Global Burden of Disease analysis, approximately 591 million individuals worldwide live with diabetes, a figure projected to reach 1.031 billion by 2050 ( As an endocrine-metabolic disease driven primarily by autoimmunity, γδ T cells may mediate either protective or destructive effects on pancreatic β-cells in T1DM

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Even so, these pathways are central to maintaining cellular and tissue function over time