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An enzyme called dipeptidyl peptidase-4 (DPP-4) cleaves and inactivates GLP-1 almost instantly, preventing it from reaching therapeutic targets in any meaningful way
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Freezing damages the peptide structure and can cause crystallization or phase separation, rendering the medication unsafe or ineffective
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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