glp 1 agonist and dpp 4 inhibitor 𝐋𝐚𝐭𝐞𝐬𝐭 𝐩𝐨𝐬𝐢𝐭𝐢𝐨𝐧 𝐨𝐟 𝐃𝐏𝐏-𝟒 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 (𝐞.𝐠., 𝐬𝐢𝐭𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐬𝐚𝐱𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐥𝐢𝐧𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐚𝐥𝐨𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐯𝐢𝐥𝐝𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧) 𝐢𝐧 𝐭𝐡𝐞 𝟐𝟎𝟐𝟓 𝐀𝐃𝐀 𝐒𝐭𝐚𝐧𝐝𝐚𝐫𝐝𝐬 𝐨𝐟 The Role of DPP-4

glp 1 agonist and dpp 4 inhibitor 𝐋𝐚𝐭𝐞𝐬𝐭 𝐩𝐨𝐬𝐢𝐭𝐢𝐨𝐧 𝐨𝐟 𝐃𝐏𝐏-𝟒 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 (𝐞.𝐠., 𝐬𝐢𝐭𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐬𝐚𝐱𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐥𝐢𝐧𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐚𝐥𝐨𝐠𝐥𝐢𝐩𝐭𝐢𝐧, 𝐯𝐢𝐥𝐝𝐚𝐠𝐥𝐢𝐩𝐭𝐢𝐧) 𝐢𝐧 𝐭𝐡𝐞 𝟐𝟎𝟐𝟓 𝐀𝐃𝐀 𝐒𝐭𝐚𝐧𝐝𝐚𝐫𝐝𝐬 𝐨𝐟 The Role of DPP-4

The Role of DPP-4 Inhibitors in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect

3 Although no studies have prospectively stratified patients by baseline A1C in evaluation of the A1C-lowering efficacy of a DPP-4 inhibitor or SGLT2 inhibitor, post-hoc subgroup analyses have shown that the efficacy of SGLT2 inhibitors is greater than that of DPP-4 inhibitors among patients with higher baseline A1C (≥ 8-8.5%), while patients with baseline A1C at the lower end of the spectrum ( 30 mL/min and clinical CV disease according to Diabetes Canada

The risk may be particularly high in patients with underlying heart failure or kidney disease