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Efficacy and safety of adding once-weekly dulaglutide to basal insulin for inadequately controlled type 2 diabetes in Chinese patients (AWARD-CHN3): A randomized, double-blind, placebo-controlled, phase III trial

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10 In particular, semaglutide was most successful at reducing alanine transaminase (mean difference, −14.70 U/L), aspartate transaminase (mean difference, −9.32 U/L), g-glutamyl transferase (mean difference, −16.56 U/L), and liver stif fness measurement (mean difference, −3.08 kPa) compared with the other medications studied, whereas liraglutide demonstrated efficacy in reducing subcutaneous adipose tissue (mean difference, −30.27 cm 2 ) and liver fat fraction (mean difference, −5.16%)