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The targeting of signaling partners to GLP-1rs is likely mediated by in some areas by A-kinase anchoring protein (AKAP) scaffolding proteins, which have been shown to target PKA to GLP-1r(Lester et al., 1997)
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A prospective clinical trial conducted in India reported a significant decrease in LFC, but liver enzymes, liver stiffness, and pancreatic fat did not show statistically significant differences after 24 weeks of treatment with dulaglutide 1.5 mg in patients with MASLD and T2DM
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