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Furthermore, in ECL1 of GCGR there are two glycine residues (G207 ECL1 , G219 ECL1 ) that disconnect the helical structure in the active state, whereas the G219 ECL1 is not conserved in GLP-1R and the helical conformation is relatively intact in this region of GLP-1R

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However, he also noted transient gastrointestinal side effects in over 30% of patients, emphasizing the need for monitoring and longer-term studies to assess safety and sustainability

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