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The percentage of patients who discontinued due to ineffective therapy was 5.4% in the liraglutide injection 1.8 mg + metformin treatment group, 3.3% in the liraglutide injection 1.2 mg + metformin treatment group, 23.8% in the placebo + metformin treatment group, and 3.7% in the glimepiride + metformin treated group

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Keywords: GLP-1, GLP-1 RAS, GLP-1R, brain inflammation, multiple sclerosis, ALS, Alzheimer’s disease, Parkinson’s disease, microglia, astrocytes 1