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“Incretin hormones” are an endocrine signal secreted by the gut after eating that stimulates insulin release in a glucose-dependent manner (Creutzfeldt, 1979)

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For example, GLP-1RAs have been shown to reduce retinal ganglion cell loss by lowering pro-apoptotic signals such as Bax and enhancing anti-apoptotic signaling via Bcl-2 pathways