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They also show promise for the treatment of many inflammatory diseases including asthma and inflammatory bowel disorders like Crohn’s disease and ulcerative colitis Diagram showing food stimulating the release of GLP-1 into the intestine and its effects on the brain, stomach and pancreas Importance In 2023 GLP-1 based drugs was named breakthrough of the year by Science , a prestigious American journal

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As mentioned previously, the A1 astrocyte phenotype, induced by microglia‐derived IL‐1α, TNFα, and C1q, loses its neuroprotective functions and secretes neurotoxic and pro‐inflammatory mediators that exacerbate neuronal damage