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The hypoglycaemic effect of GLP-1RAs is achieved by stimulating insulin secretion in pancreatic β cells, suppressing glucagon secretion in pancreatic α cells, and slowing gastric emptying

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When metformin alone is insufficient, NICE recommends considering the addition of one of several medication classes: SGLT2 inhibitors (such as dapagliflozin, empagliflozin, or canagliflozin) work by increasing glucose excretion through the kidneys