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From the New England Journal of Medicine: GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney
However, after discontinuing both the drug and lifestyle support, participants regained approximately two-thirds of their lost weight over the next year โ leaving a net weight loss of just 5.6% from baseline
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Thus, GLP-1 could improve hepatic lipid metabolism by regulation of NAMPT/SIRT1/AMPK signaling