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Our models assume that the biological activity of a peptide is dictated by its primary sequence, which we represent using simple one-hot encoding 25,26,27

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In general, the self-report data indicate that medication users often report higher doses than those recorded in their EHRs, with 88.8% of semaglutide and 84.3% of tirzepatide users self-reporting a dosage greater or equal to the EHR records