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GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide ( Mounjaro) have become incredibly common in diabetes and weight-management care, and they're now showing up more and more in the perioperative setting. These

The evidence base includes STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

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However, our current understanding likely represents a small proportion of the potential of the gut microbiota to impact metabolic homeostasis via gut–brain signaling, and this is a field that needs to continue to be explored