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"GLP-1 medications naturally reduce appetite, and for some people they also reduce thirst, so it's easier to fall behind on fluids during hot weather." The Centers for Disease Control and Prevention recommends drinking two to four glasses of fluids each hour for prevention of heat-related illness, a goal that might be harder to achieve for patients on a GLP-1

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Any changes in energy that patients experience are typically indirect effects related to weight loss, improved blood sugar control, or changes in eating patterns rather than a direct pharmacological action on energy production